Table 6.
Comparison of PK parameters in Caucasian and Korean patients after the first intravenous infusion of 100 mg BI 836826
| PK parameter | Caucasian patients | Korean patients |
|---|---|---|
| n = 6 | n = 4 | |
| Cmax, norm (ng/mL/mg) | 207 | 532 |
| AUC0-tz (ng•h/mL) | 419,000 (106) | 1,920,000 (24.7) |
| n = 3 | n = 3 | |
| AUC0-∞ (ng•h/mL/mg) | 829,000 (63.9) | 2,780,000 (61.5) |
| AUC0-∞,norm (ng•h/mL/mg) | 8290 | 27,800 |
Data are shown as geometric mean (coefficient of variation, %)
AUC0-tz area under the curve over the time interval of one treatment course, AUC0-∞ area under the curve over the time interval from zero extrapolated to infinity, Cmax maximum concentration, norm normalized, PK pharmacokinetic