Table 2.

Kinetic parameters of α-aminoalkylphosphonate diaryl ester peptidyl derivatives

No.	Structure			log EC50 [µM]	EC50 [µM]	Ki [µM]	% Inh (50 µM)
	R 1	R 2	R 3
23	-CH(CH3)2	-CH3	-CH2CH3	1.535 ± 0.031	34.25	17.00	64.1
24	-CH(CH2)5	-CH3	-CH2CH3	1.313 ± 0.053	20.54	10.19	74.1
25	-CH(CH3)2	-CH3	-CH(CH3)2	1.342 ± 0.026	21.98	10.90	81.8
26	-CH(CH2)5	-CH3	-CH(CH3)2	1.297 ± 0.033	19.83	9.84	85.8
27	-CH(CH3)2	-CH3	-C(CH3)3	1.328 ± 0.039	21.26	10.54	83.3
28	-CH(CH2)5	-CH3	-C(CH3)3	1.427 ± 0.041	26.76	13.27	77.3
29	-CH(CH3)2	-CH3	-H	1.503 ± 0.042	31.86	15.81	62.1
30	-CH(CH2)5	-CH3	-H	1.481 ± 0.060	30.24	15.00	69.0
31	-CH(CH3)2	-CH2CH3	-H	1.580 ± 0.056	37.97	18.84	57.0
32	-CH(CH2)5	-CH2CH3	-H	1.380 ± 0.074	23.97	11.89	71.0
33	-CH(CH3)2	-CH(CH3)2	-H	1.543 ± 0.052	34.96	17.35	58.5
34	-CH(CH2)5	-CH(CH3)2	-H	1.378 ± 0.034	23.85	11.83	70.5
35	-CH(CH3)2	-CH(CH3)CH2CH3	-H	1.251 ± 0.037	17.84	8.84	77.4
36	-CH(CH2)5	-CH(CH3)CH2CH3	-H	1.211 ± 0.036	16.24	8.05	81.4
37	-CH(CH3)2	-CH2CH(CH3)2	-H	1.449 ± 0.062	28.13	13.96	67.4
38	-CH(CH2)5	-CH2CH(CH3)2	-H	1.026 ± 0.051	10.61	5.25	84.2
39	-CH(CH3)2	-CH2CH2SCH3	-H	1.418 ± 0.041	26.20	13.00	65.8
40	-CH(CH2)5	-CH2CH2SCH3	-H	1.420 ± 0.028	26.31	13.05	73.8
41	-CH(CH3)2	-CH2(C6H5)	-H	-0.884 ± 0.036	0.13	0.05	100.0
42	-CH(CH 2 ) 5	-CH2(C6H5)	-H	-0.132 ± 0.034	0.74	0.35	100.0
43	-CH(CH3)2	-CH2CH2(C6H5)	-H	1.235 ± 0.048	17.17	13.00	85.4
44	-CH(CH2)5	-CH2CH2(C6H5)	-H	1.184 ± 0.046	15.27	7.57	86.5