Table 4.
All grade ADRs
| Alla) | First-line | Second-line | Third or later-line | |||||
|---|---|---|---|---|---|---|---|---|
| n = 637 | n = 142 | n = 177 | n = 317 | |||||
| n | (%) | n | (%) | n | (%) | n | (%) | |
| All grade ADR | 530 | (83.2) | 123 | (86.6) | 146 | (82.5) | 260 | (82.0) |
| Neutropenia | 373 | (58.6) | 85 | (59.9) | 110 | (62.1) | 177 | (55.8) |
| Leukopenia | 358 | (56.2) | 83 | (58.5) | 94 | (53.1) | 180 | (56.8) |
| Peripheral neuropathy | 173 | (27.2) | 44 | (31.0) | 57 | (32.2) | 71 | (22.4) |
| Lymphopenia | 93 | (14.6) | 19 | (13.4) | 25 | (14.1) | 49 | (15.5) |
| Stomatitis | 68 | (10.7) | 24 | (16.9) | 19 | (10.7) | 25 | (7.9) |
| Malaise | 64 | (10.0) | 15 | (10.6) | 26 | (14.7) | 23 | (7.3) |
| Aspartate aminotransferase increased | 48 | (7.5) | 11 | (7.7) | 12 | (6.8) | 25 | (7.9) |
| Pyrexia | 46 | (7.2) | 5 | (3.5) | 16 | (9.0) | 25 | (7.9) |
| Alanine aminotransferase increased | 39 | (6.1) | 11 | (7.7) | 11 | (6.2) | 17 | (5.4) |
| Dysgeusia | 39 | (6.1) | 8 | (5.6) | 11 | (6.2) | 20 | (6.3) |
| Nausea | 36 | (5.7) | 6 | (4.2) | 15 | (8.5) | 15 | (4.7) |
| Anemia | 34 | (5.3) | 9 | (6.3) | 7 | (4.0) | 18 | (5.7) |
Common Terminology Criteria for Adverse Events (version 4.0) all grade adverse drug reactions (ADRs) occurring in ≥5% of the patients in all groups are summarized
a)One patient whose number of previous chemotherapy regimens was unknown was included in the analysis