Table 5.
Grade ≥ 3 ADRs
| Alla) n = 637 |
First-line n = 142 |
Second-line n = 177 |
Third or later-line n = 317 |
|||||
|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | n | (%) | n | (%) | |
| Neutropenia | 315 | (49.5) | 77 | (54.2) | 86 | (48.6) | 151 | (47.6) |
| Leukopenia | 233 | (36.6) | 52 | (36.6) | 56 | (31.6) | 124 | (39.1) |
| Lymphopenia | 75 | (11.8) | 15 | (10.6) | 17 | (9.6) | 43 | (13.6) |
| Anemia | 16 | (2.5) | 5 | (3.5) | 1 | (0.6) | 10 | (3.2) |
| Gamma-glutamyl transferase increased | 18 | (2.8) | 3 | (2.1) | 6 | (3.4) | 9 | (2.8) |
| Peripheral neuropathy | 10 | (1.6) | 3 | (2.1) | 3 | (1.7) | 4 | (1.3) |
| Febrile neutropenia | 22 | (3.5) | 2 | (1.4) | 3 | (1.7) | 17 | (5.4) |
| Alanine aminotransferase increased | 10 | (1.6) | 2 | (1.4) | 2 | (1.1) | 6 | (1.9) |
| Aspartate aminotransferase increased | 14 | (2.2) | 1 | (0.7) | 2 | (1.1) | 11 | (3.5) |
| Thrombocytopenia | 7 | (1.1) | 0 | (0.0) | 2 | (1.1) | 5 | (1.6) |
Common Terminology Criteria for Adverse Events (version 4.0) grade ≥ 3 adverse drug reactions (ADRs) occurring in ≥1% of patients in all groups are summarized
a)One patient whose number of previous chemotherapy regimens was unknown was included in the analysis