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Dose levels and dose-escalation schedule for metformin
| Dose level | Dose of metformin given orally (total daily dose) | Minimum number of patients |
|---|---|---|
| -1 | 500 mg bd (1000 mg) | (3, if DLT at level 1) |
| 1 | 500 mg tds (1500 mg) | 3 |
| 2 | 850 mg tds (2250 mg) | 3 |
| 3 | 1000 mg tds (3000 mg) | 3 |
BD two times daily, DLT dose-limiting toxicity, TDS three times daily
