Table 4.

Pharmacokinetic parameters of platinum

Parameter	Unit	Carboplatin without metformin (median (IQR))	Carboplatin with metformin (median (IQR))	p value
CL	L/h	3.39 (1.2)	2.44 (1.5)	0.013
Vda	L	484 (135.6)	385 (170.9)	0.037
AUC 48 h	mg/L*h	82.8 (14.2)	91.8 (35.0)	0.028
AUC 48 h corrected for dose adjustment	mg/L*h	82.8 (14.2)	101 (44.7)	0.013

Pharmacokinetic parameters of platinum (carboplatin) when administered as combination chemotherapy with paclitaxel and with addition of metformin (n = 10 patients)

^aWith the KinFit analysis, it was determined that a three-compartment model fit the platinum levels best based on the improved p-values of the fits compared to a two-compartment model. No significant difference in volume of distribution was found in any of the three separate compartments.

Platinum AUCs of cycle 2 were corrected for carboplatin dose adjustment from cycle 1 to cycle 2 in 3 patients (dose reduction for reason of thrombocytopenia), assuming a linear relationship between dose and AUC. AUC area under the concentration-time curve, CL clearance, IQR inter quartile range, Vd total volume of distribution