Fig. 1.

a MTV for animals implanted with a single tumor. All treatments were initiated on Study Day 1, 12 days after tumor implantation when MTV = 56 to 59 mm³. Untreated group: n = 6 (one tumor in the untreated group appeared to regress at Day 16 and this animal was excluded from tumor volume comparisons), all other groups: n = 10. IV docetaxel was administered at 10 mg/kg and 5 mg/kg on Day 1 and 11, respectively (blue diamonds). NanoDoce-1 (27.5 mg/kg) and NanoDoce-2 (55 mg/kg) treatments were locally administered on Days 1, 7, and 14 (red triangles). b Day 23 MTV for animals implanted with a single tumor. * = p < 0.001 vs. IT vehicle; † = p < 0.01 vs. docetaxel. Error bars = ± 1 SEM