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. 2020 Jun 27;43(10):1045–1055. doi: 10.1007/s40264-020-00964-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Onapristone (simple oral tablet) vs onapristone extended-release (ER) pharmacokinetics on dosing day 1 and at steady state. Onapristone 100 mg once daily (QD) [capsule form] and onapristone-ER 50 mg twice daily (BID); day 1 maximum concentration (C_max) and steady-state trough concentrations (C_min,ss). Day 1 C_max for onapristone-ER 50 mg BID and onapristone 100 mg QD and C_min,_ss measured on days 8, 29, and 57. The midline on the bars represents the median, while the whiskers represent the individual C_min and C_max observed within each group. The box below the median represents the second quartile (Q2), while the box above the median represents the third quartile (Q3)