Table 2.

Unadjusted (HR) and Adjusted Hazard Ratio (AHR) of in-hospital death in 539 patients with COVID-19 disease, by univariable and multivariable Cox regression analyses.

	Unadjusted				Model1 (w Charlson index)				Model2 (w single comorbidities)
	HR	95%CI		p	AHRa	95%CI		p	AHRa	95%CI		p
Age, per 10 years older	1.55	1.39	1.74	<0.001	1.53	1.32	1.78	<0.001	1.60	1.37	1.86	<0.0001
Gender, male (vs female)	1.11	0.81	1.52	0.531	1.36	0.96	1.93	0.082	1.34	0.94	1.90	0.108
Hypertension (vs no)	1.72	1.27	2.33	<0.001					1.00	0.69	1.44	0.996
Diabetes (vs no)	1.71	1.22	2.40	0.002					1.32	0.89	1.95	0.161
Cardio-vascular diseases (vs no)	1.99	1.48	2.69	<0.001					1.13	0.77	1.65	0.525
Cerebro-vascular diseases (vs no)	1.79	1.16	2.76	0.008					0.85	0.50	1.44	0.549
Cancer (vs no)	1.85	1.17	2.92	0.008					1.31	0.78	2.21	0.304
Chronic obstructive pulmonary disease (vs no)	1.66	1.06	2.59	0.027					1.25	0.77	2.05	0.369
Chronic liver diseases	0.97	0.45	2.07	0.935
Chronic kidney diseases	1.30	1.05	1.62	0.017					1.00	0.78	1.28	0.994
Obesiy (BMI >30 kg/m2)
No	1.00				1.00				1.00
Yes	1.31	0.82	2.08	0.256	1.50	0.92	2.46	0.106	1.50	0.91	2.48	0.115
Unknown	1.32	0.94	1.86	0.105	1.17	0.82	1.68	0.384	1.25	0.86	1.80	0.236
Charlson age unadjsuted index
0	1.00				1.00
1	1.82	1.20	2.77	0.005	1.50	0.96	2.35	0.073
2	2.29	1.45	3.64	<0.001	2.10	1.27	3.48	0.004
≥3	2.97	2.05	4.31	<0.001	1.78	1.16	2.73	0.008
CRP >60 mg/L (vs ≤60 mg/L)	2.59	1.85	3.62	<0.001	2.14	1.49	3.08	<0.001	2.08	1.44	3.01	<0.001
d-dimer >1.000 ng/mL (vs ≤1.000 ng/mL)	2.33	1.62	3.34	<0.001	1.66	1.12	2.46	0.012	1.57	1.06	2.32	0.023
Severity
Mild/moderate	1.00				1.00				1.00
Severe	2.14	1.5	3.0	<0.001	1.77	1.24	2.53	0.002	1.76	1.23	2.54	0.002
Critical	7.61	4.3	13.6	<0.001	5.27	2.82	9.85	<0.001	4.97	2.65	9.31	<0.001
Thearapy combinations
No drugs	1.00				1.00				1.00
Hydroxychloroquine + heparin (±lopinavir/r or darunavir/c or azithromycin)	0.33	0.20	0.53	<0.001	0.30	0.17	0.50	<0.001	0.28	0.16	0.47	<0.001
Hydroxychloroquine + lopinavir/r or darunavir/c	0.45	0.22	0.92	0.029	0.42	0.20	0.91	0.028	0.42	0.20	0.90	0.025
Hydroxychloroquine or Hydroxychloroquine + azithromycin	0.55	0.31	1.00	0.048	0.57	0.30	1.07	0.080	0.53	0.28	1.00	0.048
Heparin	0.85	0.45	1.58	0.600	0.65	0.34	1.26	0.201	0.66	0.33	1.31	0.239
Other combinations	0.44	0.22	0.89	0.021	0.37	0.18	0.79	0.010	0.34	0.16	0.72	0.005
Week of admission
24 Feb–08 Mar 2020	1.00				1.00				1.00
09 Mar–22 Mar 2020	0.85	0.53	1.37	0.509	1.33	0.80	2.22	0.267	1.47	0.87	2.47	0.146
23 Mar–05 Apr 2020	0.68	0.41	1.11	0.122	1.05	0.60	1.86	0.857	1.11	0.61	2.01	0.739
06 Apr–19 Apr 2020	0.62	0.34	1.11	0.107	0.79	0.40	1.54	0.484	0.92	0.46	1.83	0.802
20 Apr–03 May 2020	0.88	0.45	1.73	0.717	1.48	0.67	3.27	0.338	1.69	0.76	3.76	0.195
04 May–17 May 2020	0.40	0.15	1.05	0.063	0.58	0.20	1.67	0.313	0.72	0.25	2.04	0.535

Bold values are those p values below 0.05, as statistically significant.

^aAdjsuted for all the factors showed.