Table 1.

Effects of angiotensin-converting enzyme 2 (ACE2) down-regulation and angiotensin II (AngII) signalling on endothelial cells and macrophages.

	Effects of ACE2 down-regulation				Effects of Angiotensin II signalling
Expression	Macrophages	References	Endothelial cells	References	Macrophages	References	Endothelial cells	References
TNFa	Increased	Thomas et al. (2010), Thatcher et al. (2012)	Increased	Thomas et al. (2010)	Increased	Nakamura et al. (1999), Thomas et al. (2010), Thatcher et al. (2012), Wu et al. (2020)	Increased	Ruiz-Ortega et al. 2002), Nakamura et al. (1999)
MIF	n/a		Increased	Zhong et al. (2008)	n/a		Increased	Zhong et al. (2008)
MCP1	Increased	Thomas et al. (2010)	Increased	Thomas et al. (2010)	n/a		Increased	Thomas et al. (2010)
Il-6	Increased	Thomas et al. (2010)	Increased	Thomas et al. (2010)	Increased	Nakamura et al. (1999), Thomas et al. (2010), Wu et al. (2020)	Increased	Thomas et al. (2010), Thatcher et al. (2012)
eNOS	n/a		Decreased	Zhong et al. (2008), Rabelo et al. (2016)	n/a		Decreased	Zhong et al. (2008)
iNOS	Increased	Thomas et al. (2010)	n/a		Increased	Nagareddy et al. (2005)	Increased	Vincent et al. (2000)
MMP2/9	Increased	Thomas et al. (2010)	Increased	Thomas et al. (2010)	n/a	n/a	n/a

eNOS, endothelial nitric oxide synthase; IL-6, interleukin 6; iNOS, inducible nitric oxide synthase; MCP1, monocyte chemoattractant protein 1; MIF, macrophage inhibitory factor; MMP2/9, matrix metalloproteinase 2/9; NA, not available; TNFα, tumour necrosis factor alpha.