Table 3.
Dose-dependent biocidal or virucidal activity and corresponding synergy index (SI) against enveloped DNA viruses (HSV-1 and VACV), bacterium (P. aeruginosa) and fungus (C. albicans).a
| Concentration of each component (µM) | SIb | |||||||||
| 20 | 35 | 50 | 75 | 125 | 250 | 500 | 1000 | |||
| HSV-1 | (-), α, β or γ | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | - |
| Q | ≤1.0 | 1.1 | 1.5 | 3.7 | ≥6.5* | ≥6.5 | ≥6.5 | ≥6.5 | - | |
| E | ≤1.0 | 1.2 | 2.6 | 3.5 | ≥6.5* | ≥6.5 | ≥6.5 | ≥6.5 | - | |
| Q/E | 1.1 | 3.7 | 5.7* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.8 | |
| Q/E/α | ≤1.0 | 2.2 | 6.0* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.8 | |
| Q/E/β | 1.3 | 4.0* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.6 | |
| Q/E/γ | 4.1* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.3 | |
| VACV | (-), α, β or γ | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | - |
| Q | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | 1.3 | 1.9 | ≥6.5* | ≥6.5 | - | |
| E | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | 1.2 | 1.7 | ≥6.5* | ≥6.5 | - | |
| Q/E | ≤1.0 | 1.2 | 2.8 | 4.6* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.3 | |
| Q/E/α | ≤1.0 | 1.4 | 3.7 | 4.9* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.3 | |
| Q/E/β | ≤1.0 | 1.3 | 4.0* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.2 | |
| Q/E/γ | ≤1.0 | 1.2 | 5.2* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 0.2 | |
| P. aeruginosa | (-), α, β or γ | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | - |
| Q | 1.7 | 3.2 | 4.1* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | - | |
| E | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | - | |
| Q/E | 1.7 | 3.6 | 4.5* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 1.0 | |
| Q/E/α | 1.4 | 2.7 | 4.5* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 1.0 | |
| Q/E/β | ≤1.0 | 2.1 | 4.6* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 1.0 | |
| Q/E/γ | 1.2 | 2.1 | 4.1* | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | ≥6.5 | 1.0 | |
| C. albicans | (-), α, β or γ | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | - |
| Q | ≤1.0 | ≤1.0 | 1.3 | 4.3* | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | - | |
| E | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 | - | |
| Q/E | ≤1.0 | ≥6.0* | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | 0.5 | |
| Q/E/α | ≤1.0 | ≥6.0* | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | 0.5 | |
| Q/E/β | ≤1.0 | ≥6.0* | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | 0.5 | |
| Q/E/γ | ≤1.0 | ≤1.0 | 4.6* | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | ≥6.0 | 0.7 | |
Biocidal or virucidal activity in log10 titer reduction factor recorded at room temperature after 15 min of contact time for HSV-1 (1.5 × 107 TCID50/mL), VACV (1.1 × 107 TCID50/mL), C. albicans (1.6 × 106 CFU/mL) and 5 min for P. aeruginosa (1.0 × 108 CFU/mL) with α = α-CD, β = β-CD, γ = γ-CD, Q = [DiC10][Cl] and E = C12E8.
Calculated according equation 1.
Minimum virucidal concentration (MVC), minimum bactericidal concentration (MBC) or minimum fungicidal concentration (MFC) = the lowest concentration able to reduce the titer of at least 99.99% of viruses, bacteria or fungus, respectively.