Table 3.
Results of the NBD Screening for All Patients (n = 316), for NF1 (n = 45), and for Non-NF1 Patients (n = 271) and Non-NF1 Subgroups When Compared to the Expected Population Score (Adjusted P values, *P < .05, **P < .01, ***P < .001, Including Number of Tests at T1 and T2)
| Domains | Time Points | All T1 = 149 T2 = 167 |
Non-NF1 | NF1 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All T1 = 128 T2 = 143 |
Biopsy/ Radiological Diagnosis T1 = 18 T2 = 13 |
Infratentorial Tumor Localization Following Complete or Subtotal Resection | Infratentorial Tumor Localization for Extent of Hydrocephalus at Diagnosis | All T1 = 21 T2 = 24 |
||||||
| All T1 = 43 T2 = 52 |
Vermis T1 = 22 T2 = 21 |
Cerebellar Hemisphere T1 = 19 T2 = 24 |
No/Minor T1 = 26 T2 = 27 |
Moderate/ Severe T1 = 34 T2 = 24 |
||||||
| Fluid intelligence (Gf) | T1 | 0.030* | 0.204 | 1.000 | 0.291 | 0.480 | 1.000 | 0.284 | 0.057 | 0.060 |
| T2 | <0.001*** | <0.001*** | 1.000 | 0.333 | 0.582 | 0.684 | 1.000 | 0.651 | <0.001*** | |
| Crystallized intelligence (Gc) | T1 | 0.602 | 0.329 | 1.000 | 0.834 | 0.872 | 1.000 | 0.284 | 0.704 | 0.351 |
| T2 | 0.541 | 0.344 | 1.000 | 0.512 | 0.768 | 0.684 | 0.900 | 0.903 | 0.195 | |
| Verbal short-term memory (Gsm) | T1 | 0.003** | 0.204 | 1.000 | 0.766 | 0.840 | 1.000 | 0.906 | 0.704 | <0.001*** |
| T2 | 0.018* | 0.344 | 1.000. | 0.512 | 0.768 | 0.684 | 1.000 | 0.651 | <0.001*** | |
| Visual processing (Gv) | T1 | <0.001*** | <0.001*** | 1.000 | <0.001*** | 0.008* | 0.516 | 0.662 | 0.016* | <0.001*** |
| T2 | <0.001*** | <0.001*** | 0.112 | 0.008** | 0.340 | 0.220 | 0.016* | 0.360 | <0.001*** | |
| Psychomotor speed (Gps), dominant hand | T1 | <0.001*** | <0.001*** | 0.012* | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | 0.006** |
| T2 | <0.001*** | <0.001*** | 0.008** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | |
| Psychomotor speed (Gps), nondominant hand | T1 | <0.001*** | <0.001*** | 0.030* | <0.001*** | <0.001*** | 0.018* | <0.001*** | <0.001*** | 0.004** |
| T2 | <0.001*** | <0.001*** | 0.075 | <0.001*** | <0.001*** | 0.005** | <0.001*** | <0.001*** | <0.001*** | |
| Psychomotor speed (Gps), coordination | T1 | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | 0.060 | <0.001*** | <0.001*** | <0.001*** |
| T2 | <0.001*** | <0.001*** | 0.008** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | |
| Processing speed/selective attention (Gs) | T1 | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** |
| T2 | <0.001*** | <0.001*** | 0.008** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | <0.001*** | |