Table 6.

Multivariate Analysis of Covariance—Main and Interaction Effects of the Fixed Factors (Treatment Arms, Localization, and Extent of Resection) and the Covariates (Age at Diagnosis and Sex) on NBD Screening Measures for Non-NF1 Patients (*P < .05, **P < .01, ***P < .001)

		Multivariate Effects				Univariate Effects
						Gf			Gc			Gsm			Gv			Gps dominant			Gps nondominant			Gps coordination			Gs
Variables		Pillai’s Trace	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par	F	df 1/df2	η 2 par
Fixed factors
1	Therapy	0.08	0.83	24/699	0.03	1.94	3/238	0.02	0.48	3/238	0.01	0.48	3/238	0.01	2.85*	3/238	0.04	1.62	3/238	0.02	0.36	3/238	0.00	0.34	3/238	0.00	0.94	3/238	0.01
2	Localization	0.09	1.29	16/464	0.04	4.09*	2/238	0.03	2.09	2/238	0.02	0.12	2/238	0.00	4.37*	2/238	0.04	0.35	2/238	0.00	0.29	2/238	0.00	0.26	2/238	0.00	0.01	2/238	0.00
3	Extent of resection	0.07	0.69	24/699	0.02	0.11	3/238	0.00	1.07	3/238	0.01	1.74	3/238	0.02	0.77	3/238	0.01	0.18	3/238	0.00	0.50	3/238	0.01	0.06	3/238	0.00	0.89	3/238	0.01
1 × 2		0.27	1.40*	48/1416	0.05	1.90	6/238	0.05	1.00	6/238	0.03	1.26	6/238	0.03	2.19*	6/238	0.05	1.69	6/238	0.04	0.77	6/238	0.02	0.63	6/238	0.02	1.62	6/238	0.04
1 × 2 × 3		0.23	1.74**	32/936	0.06	1.18	4/238	0.02	1.13	4/238	0.02	3.01*	4/238	0.05	1.45	4/238	0.02	2.06	4/238	0.03	0.56	4/238	0.01	1.65	4/238	0.03	1.32	4/238	0.02
Covariate
Sex		0.02	0.55	8/231	0.02	0.69	1/238	0.00	0.01	1/238	0.00	0.01	1/238	0.00	0.11	1/238	0.00	0.05	1/238	0.00	0.71	1/238	0.00	0.03	1/238	0.00	2.17	1/238	0.01
Age at diagnosis		0.06	1.71	8/231	0.06	0.81	1/238	0.00	0.30	1/238	0.00	2.06	1/238	0.01	0.27	1/238	0.00	3.50	1/238	0.01	0.76	1/238	0.00	0.57	1/238	0.00	0.50	1/238	0.00

Pillai’s Trace criterion was used instead of Wilk’s λ due to unequal covariance matrices (Box-Test: P < .05). For pairwise comparisons, mean scores were adjusted for the interrelations between the covariates and the dependent variables (M_adj.).