Table 4.
Summary of false-negative cases
| Age at Biopsy (Gender) | Bethesda Diagnosis | US Classification (ATA) (ACR-TIRADS score) | Nodule Size (cm) (maximum) | Reason for Surgery | Months Between FNA and Surgery | Surgical Pathology/Size of Tumor | AJCC |
|---|---|---|---|---|---|---|---|
| 62 (M) | FLUS | Low (3) | 1.3 | Afirma suspicious nodule other than index nodule | 2 | PTMC (0.6 cm) | T1aNxMx |
| 36 (F) | FLUS | Intermediate (5) | 3 | Compressive symptoms | 23 | FTC-MI (2.5 cm) | T2NxMx |
| 68 (M) | FLUS | High (4) | 1.1 | Development of lateral metastatic node | 27 | PTMC (0.3 cm) | T1aNx |
| 36 (F) | AUS | Low (3) | 1.8 | Increase in size | 40 | PTMC (0.5 cm) | T1aNxMx |
| 37 (M) | SFN | High (5) | 1.3 | Afirma suspicious nodule other than index nodule | 5 | PTMC (0.9 cm) | T1aNxMx |
Abbreviations: ACR, American College of Radiology; AJCC, American Joint Committee on Cancer; ATA, American Thyroid Association; AUS, atypia of undetermined significance; FNA, fine-needle aspiration; FLUS, follicular lesion of undetermined significance; FTC, follicular thyroid cancer; PTMC, micropapillary thyroid cancer; FTC-MI, minimally invasive follicular thyroid cancer, SFN, suspicious for follicular neoplasm; TIRADS, Thyroid Imaging Reporting and Data Systems.