. 2020 Jun 12;2(8):acmi000145. doi: 10.1099/acmi.0.000145

Table 1.

Patient case information

Age	Comorbidity	Presenting features	Method of identification	Susceptibility data	Treatment	Outcome
Between 60 and 70 years old	A chronic autoimmune disease that causes inflammation in connective tissues, and kidney failure	First episode: fever (38.8 °C), general malaise, and erythema of the right lower extremity. C-reactive protein: 250 mg l⁻¹. Leukocyte count: 12.7×10⁹ l⁻¹.	MALDI TOF MS* and 16S rRNA gene sequencing	First episode: resistant to cefuroxime (no disc zone diameter) and ciprofloxacin (MIC=1 mg l⁻¹) and susceptible to sulfamethoxazole-trimethoprim (MIC=0.5 mg l⁻¹) and gentamicin (MIC=2 mg l⁻¹).	First episode: cefuroxime, ciprofloxacin, sulfamethoxazole-trimethoprim	Cured
		Second episode: fever (40.1 °C), general malaise, and erythema of the left lower extremity. C-reactive protein: 314 mg l⁻¹. Leukocyte count: 16.7×10⁹ l⁻¹.		Second and third episodes: resistant to sulfamethoxazole-trimethoprim (MIC=8 mg l⁻¹) and susceptible to gentamicin (MIC=2 mg l⁻¹), colistin (MIC=0.25 mg l⁻¹), and tigecycline (MIC=0.125 mg l⁻¹).	Second episode: cefuroxime, gentamicin, doxycycline
		Third episode: fever (38.7 °C) and general malaise. C-reactive protein: 113 mg l⁻¹. Leukocyte count: 15×10⁹ l⁻¹.			Third episode: doxycycline

Age

Comorbidity

Presenting features

Method of identification

Susceptibility data

Treatment

Outcome

Between 60 and 70 years old

A chronic autoimmune disease that causes inflammation in connective tissues, and kidney failure

First episode: fever (38.8 °C), general malaise, and erythema of the right lower extremity. C-reactive protein: 250 mg l⁻¹. Leukocyte count: 12.7×10⁹ l⁻¹.

MALDI TOF MS* and 16S rRNA gene sequencing

First episode: resistant to cefuroxime (no disc zone diameter) and ciprofloxacin (MIC=1 mg l⁻¹) and susceptible to sulfamethoxazole-trimethoprim (MIC=0.5 mg l⁻¹) and gentamicin (MIC=2 mg l⁻¹).

First episode: cefuroxime, ciprofloxacin, sulfamethoxazole-trimethoprim

Cured

Second episode: fever (40.1 °C), general malaise, and erythema of the left lower extremity. C-reactive protein: 314 mg l⁻¹. Leukocyte count: 16.7×10⁹ l⁻¹.

Second and third episodes:

resistant to sulfamethoxazole-trimethoprim (MIC=8 mg l⁻¹) and susceptible to gentamicin (MIC=2 mg l⁻¹), colistin (MIC=0.25 mg l⁻¹), and tigecycline (MIC=0.125 mg l⁻¹).

Second episode: cefuroxime, gentamicin, doxycycline

Third episode: fever (38.7 °C) and general malaise. C-reactive protein: 113 mg l⁻¹. Leukocyte count: 15×10⁹ l⁻¹.

Third episode: doxycycline

*MALDI-TOF MS, matrix-assisted laser-detected ionization-time of flight mass spectrometry.