. Author manuscript; available in PMC: 2020 Sep 17.

Published in final edited form as: Eur J Cancer. 2017 Mar 26;77:13–20. doi: 10.1016/j.ejca.2017.02.020

Table 4.

Association between autophagy-related SNPs and hypertension in the validation and control cohorts.

SNP	n	Hypertension		Univariate exact logistic regression		Multivariable exact logistic regression^a
		0–1	2–3	Exact odds ratio (95% CI)	P value^b	Exact odds ratio (95% CI)	P value^b
Validation cohort (FIRE-3 bevacizumab arm)
ATG13rs13448					0.85		0.85
T/T	74	62 (84%)	12 (16%)	1 (Reference)		1 (Reference)
Any C	145	119 (82%)	26 (18%)	1.13 (0.51, 2.63)		1.13 (0.50, 2.67)
FIP200rs1129660					0.077		0.072
A/A	167	134 (80%)	33 (20%)	1 (Reference)		1 (Reference)
Any G	63	57 (91%)	6 (9%)	0.43 (0.14, 1.11)		0.41 (0.13, 1.07)
Control cohort (FIRE-3 cetuximab arm)
FIP200rs1129660					0.60		0.60
A/A	146	133 (91%)	13 (9%)	1 (Reference)		1 (Reference)
Any G	58	51 (88%)	7 (12%)	1.40 (0.45, 4.04)		1.38 (0.44, 3.97)

Multivariable model was adjusted for sex (female versus male), age (<65 versus ≤65) and BMI (<25 versus ≤25).

P value was based on exact conditional scores test from exact logistic regression.