Table 4.

Mean change in serum and plasma biomarkers in horses receiving a pelleted concentrate and supplemented with either 100 g of an inactive placebo top-dressed once daily (CON), or an active-ingredient oral joint supplement (TRT)

	Treatmenta
Item	TRT	CON	SEM	P-valueb
C2C, ng/mLc
Day 0	184.78	188.47	16.47	0.65
Day 14	198.97	213.77	16.47	0.54
Day 28	213.60	214.51	16.47	0.93
∆ 28–0	28.82	23.01	17.42	0.82
Log10 CPII, ng/mLc
Day 0	3.48	3.42	0.04	0.19
Day 14	3.48	3.47	0.04	0.45
Day 28	3.52	3.50	0.02	0.69
∆ 28-0	0.04	0.07	0.04	0.54
Log10CS846, ng/mLd
Day 0	2.67	2.65	0.14	0.87
Day 14	2.71	2.65	0.14	0.57
Day 28	2.72	2.56	0.15	0.29
∆ 28–0	0.04f	−0.09g	0.07	0.08
Log10PGE2, pg/mLe
Day 0	2.90	3.13	0.19	0.24
Day 14	2.88	3.18	0.19	0.15
Day 28	2.91	3.18	0.19	0.17
∆ 28–0	0.01	−0.12	0.20	0.49

^aTreatments consisted of either 100 g of an inactive placebo (CON) top-dressed once daily, or an active-ingredient oral joint supplement containing glucosamine, chondroitin sulfate, hyaluronic acid, methylsulfonylmethane, turmeric, resveratrol, collagen, silica, and boron (TRT).

^bMain effect of dietary treatment.

^cTRT (n = 10); CON (n = 9).

^dTRT (n = 9); CON (n = 9).

^eTRT (n = 10); CON (n = 7).

^f,g Within row, superscripts indicate tendency toward dietary treatment difference P ≤ 0.10.