Table 5.

The serum concentration (ng/mL) for biomarkers of collagen turnover and plasma concentration (pg/mL) for a biomarker of systemic inflammation over time in horses after exercise stressors conducted on days 13 and 27 in mature riding horses

	Day				Day
Item	13	14	SEM	P-valuea	27	28	SEM	P-valueb
C2C, ng/mLb	197.89	206.48	11.9	0.48	200.09	214.00	10.97	0.22
CPII, ng/mLc	3417.01h	3052.30i	168.49	0.05	3579.34	3306.88	231.69	0.26
CS846, ng/mLd,e	665.00	561.75	64.86	0.13	650.62h	529.94i	61.11	0.07
PGE2, pg/mLf,g	2016.79	1521.72	139.56	0.002	1558.21h	1269.09i	145.78	0.07

Treatments consisted of either 100 g of an inactive placebo (CON) top-dressed once daily, or an active-ingredient oral joint supplement containing glucosamine, chondroitin sulfate, hyaluronic acid, methylsulfonylmethane, turmeric, resveratrol, collagen, silica, and boron (TRT).

^aMain effect of day. There was no effect of dietary treatment or treatment × day.

^bTRT (n = 9); CON; days 13, 14 and days 27, 28.

^cTRT (n = 10); CON (n = 9); days 13, 14 and days 27, 28.

^dTRT (n = 10); CON (n = 9); days 13, 14.

^eTRT (n = 9); CON (n = 9); days 27, 28.

^fTRT (n = 10); CON (n = 8); days 13, 14.

^gTRT (n = 10); CON (n = 7); days 27, 28.

^h,iWithin row, superscripts indicate tendency toward dietary treatment difference P ≤ 0.10.