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Pharmacodynamic activated partial thromboplastin time (aPTT) response to EP-7041 in humans following continuous IV administration for 5 d. At 0.6 mg/kg/hr, the mean increase in aPTT was 1.7 compared with baseline, importantly with no off-target change in prothrombin time (PT). In addition, the results highlight the rapid onset, prompt clearance, and predictable dose-related elevations in the pharmacodynamic marker, aPTT.
