Figure 3.

Preclinical efficacy and safety of EP-7041 versus unfractionated heparin (UFH) in standard ferric chloride thrombosis (A) and mesenteric artery bleeding (B) models in the rat. Results showed an equivalent effect of EP-7041 and UFH on average (Avg.) clot size, but unlike UFH, that demonstrated an increase in bleeding times at its minimum efficacious dose (dose titrated to human target (international normalized ratio [INR] 2-3; 25 U/Kg + 50 U/Kg/hr) and marked bleeding at just twice this dose), EP-7041 was without an appreciable increase in bleeding, even at dose levels 30-fold greater than those that afforded efficacy (*p < 0.05; Unpublished data).