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. 2020 Aug 2;63(17):9340–9359. doi: 10.1021/acs.jmedchem.0c00522

Table 5. Inhibitory Activities of LEI-301 for Metabolic Enzymes of the ECSa.

remaining enzyme activity at 10 μM LEI-301 (% ± SD; n = 3)
hNAPE-PLD hPLA2G4E mDAGLα mDAGLβ hMAGL mFAAH mABHD6
92 ± 8 95 ± 5 97 ± 10 83 ± 1 105 ± 19 108 ± 4 92 ± 5
a

Activities were obtained from surrogate (hNAPE-PLD) or natural (hMAGL) substrate assays. hPLA2G4E, mDAGLα/β, mFAAH, and mABHD6 were determined by gel-based ABPP.