Table 1.
Clinical characteristics and MRS-FR measurements of patients with GL and PL.
| GL (n=13) | PL (n=21) | p | |
|---|---|---|---|
| Age (years) | 21 (14.5–30) | 34.0 (27–41.5) | 0.002 |
| Gender (M/F) | (4/9) | (4/17) | 0.679 |
| BMI (kg/m2) | 19.8 (17.7–21.7) | 21.8 (19.9–26.6) | 0.042 |
| Triglyceride (Normal<150 mg/dL) | 581 (332–1,347) | 377 (213–731) | 0.141 |
| ALT (Normal: 10–37 U/L) | 36 (21–56) | 23.6 (18.5–38) | 0.320 |
| AST (Normal: 10–34 U/L) | 29 (17.5–52.5) | 26 (17.5–39.5) | 0.570 |
| GGT (Normal: 10–44 U/L) | 36 (18–64.5) | 34 (27.5–70) | 0.395 |
| HbA1c (Normal: <5.7%) | 7 (6–10.7) | 8.4 (6.2–9.2) | 0.972 |
| Total cholesterol (Normal: <200 mg/dL) | 169 (147.5–257) | 195 (163–234) | 0.304 |
| HDL (Normal: >40 mg/dL M; >50 F) | 27 (18.5–30.5) | 32 (25–40.5) | 0.030 |
| LDL (Normal: <130 mg/dL) | 97 (70.5–115) | 100 (69.5–122.5) | 0.972 |
| Leptin (ng/mL) | 0.40 (0.1–0.73) | 3.34 (1.39–6.65) | <0.001 |
| Adiponectin (ng/mL) | 0.72 (0.48–3.8) | 3.84(1.65–9.23) | 0.011 |
| MRS-FR (%) | 75% (56–83%) | 72% (66–79%) | 0.901 |
All the values are presented as the median (25th–75th percentiles).
GL: generalized lipodystrophy; PL: partial lipodystrophy; M: male; F: female; BMI: body mass index; ALT: alanine transaminase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; HbA1c: glycosylated hemoglobin; HDL: high-density lipoprotein; LDL: low density lipoprotein; MRS-FR: MRS fat ratio; MRS: magnetic resonance spectroscopy.