Table 2.
Clinical characteristics and MRS-FR measurements of patients with congenital and acquired lipodystrophy.
| Congenital lipodystrophy (n=26) | Acquired lipodystrophy (n=8) | p | |
|---|---|---|---|
| Age (years) | 30.5 (21.7–39.2) | 26.0 (16.7–33.5) | 0.382 |
| Gender (M/F) | (4/22) | (4/4) | 0.066 |
| BMI (kg/m2) | 20.8 (19.3–23.9) | 21.8 (19.1–25.9) | 0.823 |
| Triglyceride (Normal: <150 mg/dL) | 484 (309–866) | 338 (191–1,367) | 0.570 |
| ALT (Normal: 10–37 U/L) | 34 (18.7–50.7) | 23.3 (19.2–43.5) | 0.489 |
| AST (Normal: 10–34 U/L) | 28 (18.7–45.5) | 22 (14–45.2) | 0.310 |
| GGT (Normal: 10–44 U/L) | 29.5 (21–54) | 67.5 (35.7–78.7) | 0.027 |
| HbA1c (Normal: <5.7%) | 8 (6.2–9.2) | 8.7 (6.2–12) | 0.465 |
| Total cholesterol (Normal: <200 mg/dL) | 181 (157–237) | 186 (157–261) | 0.919 |
| HDL (Normal: > 40 mg/dL M; >50 F) | 29 (22–36) | 28.5 (23.7–39.2) | 0.903 |
| LDL (Normal: <130 mg/dL) | 97.5 (70.7–123.7) | 98 (59.5–116.2) | 0.700 |
| Leptin (ng/mL) | 1.05 (0.53–6.22) | 1.59 (1.2–4.37) | 0.626 |
| Adiponectin (ng/mL) | 3.69 (0.86–9.99) | 2.34 (0.95–3.3) | 0.256 |
| MRS-FR (%) | 75% (66–83%) | 57% (17–76%) | 0.042 |
All the values are presented as the median (25th–75th percentiles).
M: male; F: female; BMI: body mass index; ALT: alanine transaminase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; HbA1c: glycosylated hemoglobin; HDL: high-density lipoprotein; LDL: low density lipoprotein; MRS-FR: MRS fat ratio; MRS: magnetic resonance spectroscopy.