Table 1.
General characteristics of the population enrolled. The summary datarefer to the entire population of each study. Frequencies are reported as count (%). []: Interquartile range; ICU: Intensive care unit; NOS: Newcastle-Ottawa quality assessment scale; NR: Not reported; SD: Standard deviation: VTE: Venous Thromboembolism.
| Author | Study design | Mean age (years) | Number of patients | Males N, (%) | Arterial hypertension N, (%) | Diabetes N, (%) | Active cancer N, (%) | Cerebrovascular disease | Previous VTE | Setting | NOS | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ICU | General wards | |||||||||||
| Lodigiani et al. [1] | Retrospective Single center |
66 [55–75] | 388 | 264 (58) |
183 (47) |
88 (23) |
25 (6) |
20 (5) |
12 (3) |
X | X | 8 |
| Poissy et al. [16] | Retrospective Single center |
57 | 107 | 13/22⁎⁎ (59.1) |
NR | NR | NR | NR | NR | X | 7 | |
| Grillet et al. [17] | Retrospective Single center |
66 (SD:13) | 100 | 70 (70) |
NR | 20 (20) |
20 (20) |
NR | NR | X | X | 7 |
| Leonard-Lorant [8] | Retrospective Double-center |
63.5 | 106 | 70 (66) |
NR | NR | NR | NR | NR | X | X | 7 |
| Llitjos et al. [3] | Retrospective Double-center |
68 [51.7–74.5] | 26 | 20 (77) |
22 (85) |
NR | 0 | NR | 1 (4) |
X | 7 | |
| Klok et al. [18] | Retrospective multicenter | 64 (SD:12) | 184 | 139 (76) |
NR | NR | 5 (3) |
NR | NR | X | 8 | |
| Thomas et al. [19] | Retrospective Single center | 59 (SD:13) | 63 | 44 (69) |
NR | NR | NR | NR | NR | X | X | 7 |
| Middeldorp et al. [20] | Retrospective single center | 61 (SD:14) | 198 | 130 (66) |
NR | NR | 7 (3) |
NR | 11 (5) |
X | X | 8 |
| Helms et al. [4] | Retropsective Multicenter | 63 [53–71] | 150 | 122 (81) |
NR | 30 (20) |
9 (6) |
72 (48) |
8 (5) |
X | 8 | |
| Galeano-Valle et al. [21] | Prospective Single center |
64.3 (SD:14.4) | 24 | 14 (58.) |
NR | NR | 1 (4) |
NR | NR | X | 8 | |
| Bompard et al. [12] | Retrospective Double center |
64 [64–76] | 135 | 94 (70) |
NR | NR | NR | NR | NR | X * | 7 | |
| Soumagne et al. [22] | Retrospective Multicenter |
63.5 (SD:10.1) |
375 | 288 (77) |
216 (58) |
99 (26) |
44 (12) |
NR | NR | X | 7 | |
| Freund et al. [23] | Retrospective Multicenter |
61.0 (SD: 19) |
3253 | 1558 (47.8) |
1294 (40) |
NR | 442 (13.5) |
NR |
385 (11.8) |
X° | 7 | |
| Chen et al. [24] | Retrospective Single center |
65 [56.5–70] | 25 | 15 (60) |
10 (40) |
5 (20.0) |
0 | NR | NR | X | 7 | |
| Longhcamp et al. [25] | Retrospective Single center |
68 (SD: 11) |
25 | 16 (64) |
10 (40) |
1 (4) |
2 (8) |
NR | 0 | X | 6 | |
| Whyte et al. [26] | Retrospective Single center |
61.5 | 214 | 129 (60.2) |
NR | NR | 16 (7) |
NR | 21 (10) |
X | X | 7 |
| Marone et al. [27] | Retrospective Single center |
NR | 101 | NR | NR | NR | NR | NR | NR | X | 5 | |
| Fauvel et al. [28] | Retrospective Multicenter |
64 (SD:17) |
1240 | 721 (58) |
559 (45) |
268 (22) |
167 (13.5) |
94 (8) |
98 (8) |
X | X | 8 |
| Van den Heuvel [29] | Retrospective Single center |
63 [51–68] |
51 | 41 (80) |
21 (41) |
9 (18) |
NR | 2 (4) |
NR | X | 6 | |
| Mestre-Gomez et al. [30] | Retrospective Single center |
65 [56–73] |
29 | 21 (72) |
12 (41) |
3 (10.0) |
5 (17) |
1 (3) |
1 (3.4) |
X | 7 | |
| van Dam et al. [31] | Retrospective Single center |
63 (SD:6.4) |
23 | 16 (70) |
NR | NR | 1 (4) |
NR | 1 (4) |
X | 7 | |
| Gervaise et al. [32] | Retrospective Single center |
62.3 (SD:17.8) |
72 | 54 (75) |
NR | NR | NR | NR | NR | X | 6 | |
| Trimaille et al. [33] | Retrospective Single center |
62.2 (SD:17.0) |
289 | 171 (59) |
132 (46) |
59 (20) |
8 (3) |
NR | 28 (10) |
X | 8 | |
⁎
Only ICU patients were considered in the analysis since some cases of acute pulmonary embolism in non-ICU setting were also observed in outpatients.
⁎⁎
Referred to patients with acute Pulmonary embolism.° Emergency department (ED).