Table 1.
Bona fide direct transcriptional targets of EPR
| Gene name | Known biological function | TGF-β | Gene name | Known biological function | TGF-β |
|---|---|---|---|---|---|
| Anks4b | Intermicrovillar adhesion regulator | • | Hdac11 | Histone deacetylase | • |
| Arrdc3 | Negative regulator of locomotion | • | Hectd2 | Ubiquitin protein ligase | |
| Cdkn1a | Negative regulator of cell growth | Kif13b | Cytoskeleton reorganizer | • | |
| Celsr1 | Cell adhesion regulator | • | Man2b2 | Protein deglycosylase | |
| Cndp2 | Glutathione biosynthetic process regulator | Myo1d | Microfilament motor activity regulator | • | |
| Cp | Copper/iron ions transporter | • | Naip2 | Inflammasome complex component | • |
| Cpne8 | Modulator of cellular response to calcium ion | Nrbp2 | Intracellular signal transducer | ||
| Cth | Cysteine biosynthetic process component | • | Ocln | Cell-cell junction organizer | • |
| Cxcl5 | Chemokine-mediated signaling pathway component | • | Parm1 | Endoplasmic reticulum component | |
| Dnm1 | Receptor-mediated endocytosis regulator | Pik3c2b | PI3K family member, cell-cell junctions | • | |
| Ddit4 | Negative regulator of TOR signaling | Pilrb2 | Immune system regulator | • | |
| Endod1 | Endonuclease | Plac8 | Chromatin binding protein | • | |
| Erbb3 | Growth factor receptor, tight junctions component | • | Plekha7 | Epithelial cell-cell adhesion regulator | • |
| Fignl2 | Microtubule dynamics regulator | Scamp5 | Regulator of calcium-dependent exocytosis | • | |
| Fgd1 | Actin cytoskeleton organizer | Slc12a2 | Regulator of ionic balance and cell volume | • | |
| Fst | Activin antagonist | Smagp | Regulator of epithelial cell-cell contacts | • | |
| Gclc | Component of the cellular response to various stimuli | • | Spint2 | Negative regulator of cell motility | • |
| Gimd1 (Gm5549) | GTP binding protein | • | Stap2 | Signaling linker | • |
| Gsap | Regulator of proteolysis | • | Syt7 | Regulator of calcium-dependent exocytosis | |
| Grtp1 | GTPase activator | • | Tob1 | Anti-proliferative factor | • |
| H6pd | Glucose metabolism regulator, hallmark of EMT | • | Wfdc2 | Protease inhibitor | • |
List of bona fide direct transcriptional target genes of EPR. Dots mark genes whose expression is significantly down-regulated by TGF-β (24 h treatment, P< 0.001, Student's t test, see (36)).