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. 2020 Jul 29;48(16):9019–9036. doi: 10.1093/nar/gkaa625

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Many ciliopathy genes are direct targets of RFX1, RFX2 and/or RFX3. The histograms show the fold change in expression (log2 FC) in Rfx2⁻^/⁻ and Rfx3⁻^/⁻ cells for 187 mouse orthologs of genes that are affected in human ciliopathies. The presence RFX1, RFX2 and/or RFX3 ChIP-seq peaks in their promoters is indicated at the right. Significant reductions in gene expression are highlighted in light (Rfx3⁻^/⁻ cells) or dark (Rfx2⁻^/⁻ cells) grey, whereas non-significant variations are indicated in orange (Rfx3⁻^/⁻ cells). Genes highlighted in red are orthologs of human genes implicated in Primary Ciliary Dyskinesia (PCD). Nearly all of these PCD genes are direct targets of RFX1, RFX2 and/or RFX3, and are downregulated significantly in Rfx2⁻^/⁻ and/or Rfx3⁻^/⁻ cells. All genes have at least one X-box motif in their promoter, except for those indicated in black font.