Figure 6.

Functional organization of selected CARF domain-encoding loci. For each locus, species name and genome accession number are indicated. Genes are shown by arrows roughly to scale. Dashed line between arrows indicated that the loci encoded far from each other. Arrows are color-coded according to the scheme below. The gene names largely follow the nomenclature from (1), but the RAMP proteins of groups 5 and 7 and small subunits are denoted gr5, gr7 and gr11, respectively. The CRISPR–Cas system subtype is indicated on the left. Experimentally characterized ring nucleases are denoted by small red circle above the respective arrows.