Table 3.

Mammalian hcoErosions that either have an RVIS (Residual Variation Intolerance Score) in the bottom quintile of all human genes analyzed and/or have a pLI (probability of being loss-of-function intolerant) score ≥ 0.9 (✓)

Gene	RVIS percentile	gnomAD pLI score ≥ 0.9	Species with hcoErosion
UBC	4.19%		(I) Hedgehog, Star-nosed mole, Shrew
			(II)Naked mole-rat, Guinea Pig, Chinchilla, Brush-tailed rat
			(III)Ferret, Panda, Pacific walrus, Weddell seal
			(IV)Alpaca, Bactrian camel
DDX60	6.02%		Tibetan antelope, Sheep, Domestic goat, Cow
PCDHA7	10.27%		Panda, Weddell seal, Ferret, Pacific walrus
ADAM30	10.78%	N/A	Guinea Pig, Brush-tailed rat, Naked mole-rat, Chinchilla
ZYG11B	14.34%	✓	Rhesus macaque, Crab-eating macaque
PPP2R2D	18.43%	✓	Tibetan antelope, Sheep, Domestic goat, Cow
DCAF12L1	22.73%	✓	Naked mole-rat, Guinea Pig, Chinchilla, Brush-tailed rat

^{(I), (II), (III), (IV )} Independent hcoErosion loss events:

^(I) species belonging to group I ^(II) species belonging to group II ^(III) species belonging to group III ^(IV) species belonging to group IV.