Table 1.
Synergistic interaction of pol2-P301R and MMR deficiency
| CAN1 mutation | his7-2 reversion | |||
|---|---|---|---|---|
| Genotype | Mutation rate (×10−7) | Fold increase | Mutation rate (×10−8) | Fold increase |
| POL2/POL2 MSH6/MSH6 | 3.4 (3.0–4.0) | 1 | 1.1 (0.85–1.3) | 1 |
| POL2/POL2 msh6Δ/msh6Δ | 31 (28–36) | 9.1 | 4.6 (4.1–5.3) | 4.2 |
| POL2/pol2-P301R MSH6/MSH6 | 75 (70–93) | 22 | 29 (25–33) | 26 |
| POL2/pol2-P301R msh6Δ/msh6Δ | 4300 (3300–6000) | 1300 | 105 (73–230) | 95 |
Mutation rates are medians for at least 18 cultures from two to three independent clones. 95% confidence intervals are shown in parentheses.