Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 18;39(38):6099–6112. doi: 10.1038/s41388-020-01417-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a Gene expression of MARC2 in different copy number groups. Shallow deletion: 0.5; Diploid: 1; Gain: 1.5; Amplification: 2. b Correlation between MARC2 gene expression and methylation score of MARC2. The Pearson correlation coefficient was used to determine the relationship. c Heatmap for the CpG sites of MARC2. N represented the normal tissue (n = 50), and T represented the tumor tissue (n = 377). d Correlation between MARC2 gene expression and methylation score of cg05797615. The Pearson correlation coefficient was used to determine the relationship. e The Kaplan–Meier method was used to compare the OS between the patient group with high methylation score of cg05797615 and patient group with low methylation score of cg05797615. f, g 0, 1, 2 µmol 5-Aza-2′-deoxycytidine was added to HCCLM3 and Huh7 cell lines respectively. qPCR was used to analyze the gene expression of MARC2 in HCCLM3 and Huh7 cell lines treated with 5-Aza-2′-deoxycytidine at 24 h and 48 h. h–m Pyrosequencing was used to analyze the methylation level of cg05797615 in HCCLM3 and Huh7 cell lines treated with 5-Aza-2′-deoxycytidine in the left panel and statistical analysis in the right panel. *p < 0.05; **p < 0.01; ***p < 0.001.