Fig. 4.

Schematic representation of the hormetic responses to tau and Aß concentration. There is an optimal concentration of tau or Aβ for a number of physiological functions. Too little protein (or loss of function modifications) or too much protein (or gain of function modifications) can both disrupt normal function. Effectively rescuing loss of function or preventing gain of function to maintain optimal physiological conditions should be the ultimate goal of therapeutics. Created with https://biorender.com/