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. 2020 Sep 17;10:15255. doi: 10.1038/s41598-020-71994-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental design. Mice were habituated to cup handling before they underwent daily training sessions until successful acquisition of the discrimination task. Afterwards, they were tested in the cognitive judgement bias (CJB) test. During the following phase, mice repeatedly made one out of three different experiences: mildly “adverse”, “beneficial”, or “neutral”. They were then tested for their CJB again. During this second test phase, a so-called reminder was presented before each test session with the aim to re-evoke the affective state the animals experienced during the treatment phase. On the last day of each CJB test phase, faecal corticosterone metabolite concentrations (FCMs) were assessed. Subsequently, animals were tested for anxiety-like behaviour. Again, they were presented with reminders before each behavioural test.