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. 2020 Sep 17;11(9):769. doi: 10.1038/s41419-020-02944-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Cytosolic Ca²⁺ measurement in Fura-2 AM loaded SU-DHL-4 (left) and OCI-LY-1 (right) cells. The compound was added after 60 s (DMSO as control, BDA-366 or IgG/IgM) at the indicated concentrations. Each curve represents the F340/F380 ratio as function of time for cell populations from three separate wells, which were considered as technical replicates. One representative experiment (out of six or four independent experiments, presented in Supplementary Fig. 5) is shown in panel (a). b Single cells cytosolic Ca²⁺ measurement in Fura-2 AM loaded primary CLL samples. Each curve represents the F340/F380 ratio as a function of time for an individual cell. In each experiment, at least 20 cells were measured. One representative experiment (out of three independent experiments) is shown in panel (b). Data are representative of three independent measurements per patient sample (CLL-G431 and CLL-M394).