Fig. 8.

AL002a positively impacts axonal health after CPZ-induced demyelination. a Neurofilament light chain (Nf-L) levels were measured in plasma samples collected from Trem2^+/− naïve mice and Trem2^+/− mice treated with AL002a antibody or CTR at WK 4 +3D and WK 4 + 7D after CPZ-induced CNS demyelination. Naïve mice, N = 9; CTR group: WK 4 + 3D N = 10; WK 4 + 7D N = 10; AL002a-treated group: WK 4 + 3D N = 10; WK 4 + 7D N = 8. *P < 0.05, **P ≤ 0.01; one-way ANOVA with Tukey’s post hoc test. b Representative images and c quantification of SMI31 (red) fluorescent staining at WK 4 + 3D and WK 4 + 7D in the CC. CTR group: WK 4 + 3D N = 6 mice, n = 12 fields; 4 + 7D N = 5, n = 10; AL002a-treated group: WK 4 + 3D N = 6, n = 12; WK 4 + 7D N = 5, n = 10 fields; *P < 0.05; two-tailed unpaired Student’s t test