Table 2.
Key points | ||
---|---|---|
IgE-mediated FA | Milk | The effectiveness of CM early introduction in allergy prevention has not been demonstrated by the only one interventional study evaluating CM early introduction. |
Egg | Although two interventional studies suggested a positive effect of the early introduction strategy for HE allergy prevention, the other four did not confirm this result. | |
Peanut | Two interventional studies suggested a positive effect of peanut early introduction in PA prevention. | |
Cereal and fish | Effectiveness of early introduction in fish allergy prevention has not been demonstrated by the only one interventional study evaluating fish early introduction. In the same study, no cases of wheat allergy were reported. | |
Non-IgE-mediated FA | FPIES | Currently, the first-line approach is the strict avoidance diet of offending foods, followed by periodic re-evaluation of tolerance achievement by OFC, according to allergen and patient clinical history. |
FPIAP | Avoidance diet should not be univocally advised in breastfed infants with FPIAP and their mothers; spontaneous resolution of symptoms could be expected if rectal bleeding has lasted <1 month. | |
FPE | Avoidance of culprit food, sometimes associated to extensively hydrolyzed formula, determines the rapid resolution of symptoms. |
FA, Food allergy; CM, cow's milk; HE, hen's egg; PA, peanut allergy; OFC, oral food challenge; FPIES, food protein induced enterocolitis syndrome; FPIAP, food protein–induced allergic proctocolitis; and FPE, food protein–induced enteropathy.