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. 2020 Sep 4;7:484. doi: 10.3389/fmed.2020.00484

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Copyright © 2020 Wu, Chen, Lv, Gao, Liu, Zhao, Chen, He, Chu, Wu, Ou, Wen, Zhang, Peng, Huang, Jakobsson, Huang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Over time measurements of primary and secondary efficacy endpoints in the ITT analysis. A comparison between two combination treatments was performed by using the chi-square test or Fisher's exact test. ACR, American College of Rheumatology; cDAI, clinical disease activity index; EULAR, European League Against Rheumatism; ITT, intention-to-treat.