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. 2020 Sep 4;7:484. doi: 10.3389/fmed.2020.00484

Table 5.

Summary of adverse events in the safety analysis set.

Adverse events MTX + HQT (n = 45) MTX + LEF (n = 45) P
All 11 (24.4%) 17 (37.8%)
ALT/AST elevation 0 (0%) 4 (8.9%) 0.117
Gastrointestinal reactions 9 (20.0%) 10 (22.2%) 0.796
Rash 1 (2.2%) 1 (2.2%) 1.000
Atrial fibrillation 1 (2.2%) 0 (0%) 1.000
Leukopenia 0 (0%) 1 (2.2%) 1.000
Hypertension 0 (0%) 1 (2.2%) 1.000

Data are presented as n (%).

ALT, alanine aminotransferase; AST, aspartate aminotransferase.