Table 3.
Multiple regression between change of MRI metrics and change of clinical scores.
| Stepwise regression | LOOCV | ||||||
|---|---|---|---|---|---|---|---|
| Adjusted-R2 | P-value | Minimum, maximum, lambda | Corr-P | Spearman ρ | P-value | Corr-P | |
| T25FWT | 0.07 | 0.233 | — | 1 | — | — | — |
| 9-HPT | 0.48 | 0.003 | — | 0.03 | 0.52 | 0.002 | 0.02 |
| PASAT | 0.46 | 0.001 | (−11,24,0.4) | 0.01 | 0.56 | 0.001 | 0.008 |
| SRT-LTS | 0.39 | 0.004 | (−8,21,0.4) | 0.04 | 0.4 | 0.025 | 0.2 |
| SRT-CLTR | 0.24 | 0.03 | — | 0.27 | 0.43 | 0.013 | 0.1 |
| SRT-D | 0.57 | 0.0003 | (−2,4,0.8) | 0.003 | 0.45 | 0.009 | 0.08 |
| SPART 10/36 | 0.07 | 0.074 | — | 0.66 | — | — | — |
| WLG | 0.43 | 0.003 | — | 0.03 | 0.64 | 0.0001 | 0.001 |
| SDMT | 0.04 | 0.146 | (−96,16,2.4) | 1 | — | — | — |
Stepwise regression: The given P-values and Corrected P-values (Corr-P) are before and after Bonferroni correction, respectively. LOOCV: Spearman's rank correlation coefficient (ρ) between real and predicted outcome obtained through “leave-one-out” cross-validation (LOOCV). T25FWT, Timed25-Foot Walk Test- leg function; 9-HPT, 9-Hole Peg Test—arm function; PASAT, paced auditory serial addition test; SRT-LTS, selective reminding test-long-term storage; SRT-CLTR, selective reminding test-consistent long-term storage; SRT-D, selective reminding test-delayed recall; SPART 10/36, spatial recall test; WLG, word list generation; SDMT, symbol digit modality test. Bold values indicates the statistically significant values.