Skip to main content
. 2020 Sep 17;11:4654. doi: 10.1038/s41467-020-18508-3

Fig. 1. Chromatin accessibility in bovine oocytes and in vitro preimplantation embryos.

Fig. 1

a Schematic of in vitro embryo production and ATAC-seq library preparation. b Principal components analysis (PCA) of ATAC-seq signal, normalized by fragments per kilobase million (FPKM), in 500 bp windows covering the whole genome. c Normalized coverage (FPKM) of replicate ATAC-seq libraries for each stage of development. d Proportion of genome that is covered by genic and intergenic ATAC-seq peaks, called from 30 million reads for each developmental stage. e Categorization of ATAC-seq peaks in 2-, 4-, and 8-cell embryos into stage-specific and maintained peaks (accessibility maintained up until the morula stage). Maintained peaks are carried over from latter stages to show cumulative maintained peaks. Source data are provided as a Source Data file.