Fig. 8. Comparison of enriched motifs in open chromatin during cattle, human, and mouse preimplantation development.

a PCA comparing the percent of ATAC-seq peaks that contained a given TF motif for each cell type and species. b Inference of key regulatory factors during EGA in cattle, human, and mouse, based on enrichment of TF binding motifs in open chromatin and expression of the corresponding TFs. For motif enrichment, binomial test p values reported. Bovine RNA-seq data from Graf et al.³² human ATAC-seq and RNA-seq data from Wu et al.¹⁸ mouse ATAC-seq and RNA-seq from Wu et al.¹⁷. Source data are provided as a Source Data file.