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. 2020 Sep 17;10:15316. doi: 10.1038/s41598-020-72136-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of STAT3 decoy ODN transfection on elevated pro-inflammatory cytokines in mice following CLP-induced sepsis. (A) Blood levels of IL-1β, IL-6, TNF-α, and MCP-1. The blood was collected 18 h after surgery (n = 6), and those cytokine levels were measured by the use of ELISA. (B–E) Transcription levels of IL-1β, IL-6, TNF-α, and MCP-1 in lung, liver, kidney, and heart tissues. Tissues were harvested 18 h after surgery (n = 6). The mRNA levels were quantified by real-time PCR. The values were expressed as a fold increase above sham-operated control normalized GAPDH. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the respective control (18 h after sham operation). ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 compared with CLP alone.