Fig. 1.

Brain function in normal aging and Alzheimer's disease is influenced by lifestyle factors. The usual trajectory for brain aging (orange line) indicates that, years before death, an individual shows signs of mild cognitive impairment. In some cases, that cognitive damage takes place many years before death and even leads to dementia (red line). By modifying lifestyle factors through multimodal interventions, an individual can delay the onset of cognitive impairment until a very advanced age (green line).