Table 1.
MicroRNAs target various cellular signaling pathways.
| miR | mRNA target | Tissue/cell line | Seed location in 3′ UTR (hsa) | PMID | Human reference target mRNA | miR sequence |
|---|---|---|---|---|---|---|
| miR-28-5p | NFE2L2 | MCF-12A, MCF-7 and HEK293T cells | 55 | 21638050 | NM_001145413 | AAGGAGCUCACAGUCUAUUGAG |
| miR-93-5p | NFE2L2 | mouse N2A cells | 186 | 27300700 | NM_001145412 | CAAAGUGCUGUUCGUGCAGGUAG |
| miR-93-5p | NFE2L2 | MCF-10A and T47D human breast cancer cell line | 186 | 23492819 | NM_001145412 | CAAAGUGCUGUUCGUGCAGGUAG |
| miR-153-3p | NFE2L2 | SH-SY5Y neuronal cells | 98 | 23236440 | NM_001145412 | UUGCAUAGUCACAAAAGUGAUC |
| miR-27a-3p | NFE2L2 | SH-SY5Y neuronal cells | 62 | 23236440 | NM_001145412 | UUCACAGUGGCUAAGUUCCGC |
| miR-142-5p | NFE2L2 | SH-SY5Y neuronal cells | 83 | 23236440 | NM_006164 | CAUAAAGUAGAAAGCACUACU |
| miR-144-3p | NFE2L2 | SH-SY5Y neuronal cells | 265, 370 | 23236440 | NM_006164 | UACAGUAUAGAUGAUGUACU |
| miR-200a-3p | KEAP-1 | Rat hepatic stellate cell | 131 | 25049078 | NM_203500 | UAACACUGUCUGGUAACGAUGU |
| miR-200a-3p | KEAP-1 | MDA-MB-231 and Hs578T cells | 131 | 21926171 | NM_012289 | UAACACUGUCUGGUAACGAUGU |
| miR-200a-3p | KEAP-1 | Mahlavu and HuH7 cells | 131 | 23857252 | NM_203500 | UAACACUGUCUGGUAACGAUGU |
| miR-196a-5p | Bach1 | mouse embryonic fibroblast cells | 2161, 2280 | 27343195 | NM_001186 | UAGGUAGUUUCAUGUUGUUGGG |
| miR-196a-5p | Bach1 | 9-13 human hepatoma cells | 2161, 2280 | 20127796 | NM_001186 | UAGGUAGUUUCAUGUUGUUGGG |
| miR-155-5p | C/EBPβ | human and mouse mesenchymal stem cells | 554 | 28967703 | NM_001285878 | UUAAUGCUAAUCGUGAUAGGGGUU |
| miR-128-3p | MAFG | HEK293 and C2C12 cells | 1564 | 29138682 | NM_032711.4 | UCACAGUGAACCGGUCUCUUU |
| miR-195-3p | HIF-1α | ATDC 5 and HEK293T cells | 803 | 25753868 | NM_001243084 | CCAAUAUUGGCUGUGCUGCUCC |
| miR-199a-5p | HIF-1α | A2780 cells | 177 | 24706848 | NM_181054 | CCCAGUGUUCAGACUACCUGUUC |
| miR-217-5p | PGC-1α | MCF-7, MDA-MB-231 and HEK-293T cells | 3746 | 27916422 | NM_013261 | UACUGCAUCAGGAACUGAUUGGA |
| miR-494-3p | PGC-1α | 3T3-L1 white and beige adipocytes | 3788 | 30305668 | NM_013261 | UGAAACAUACACGGGAAACCUC |
| miR-34a-5p | SIRT1 | primary rat hepatocytes | 891, 1434 | 24421392 | NM_001142498 | UGGCAGUGUCUUAGCUGGUUGU |
| miR-34a-5p | SIRT1 | HCT116 cells | 891, 1435 | 18755897 | NM_001142498 | UGGCAGUGUCUUAGCUGGUUGU |
| miR-133a-3p | SIRT1 | H9c2 cells | 403 | 29487709 | NM_001142498 | UUUGGUCCCCUUCAACCAGCUG |
| miR-504-5p | NRF-1 | CNE2 and HEK 293 cells | 506 | 26201446 | NM_001040110 | AGACCCUGGUCUGCACUCUAUC |
| miR-494-3p | SIRT3 | SH-SY5Y neuronal cells | 1618 | 29567426 | NM_012239.6 | UGAAACAUACACGGGAAACCUC |
Abbreviations: Bach1 = transcription regulator protein BACH1; C/EBPβ = CCAAT/enhancer-binding protein β; HEK = human embryonic kidney; HIF-1α = hypoxia-inducible factor 1-α; KEAP-1 = Kelch-like ECH-associated protein 1; Maf = musculoaponeurotic fibrosarcoma; MAFG = v-Maf avian Maf oncogene homolog G; miR = microRNA; NFE2L2 = nuclear factor erythroid 2-related factor 2; NRF-1 = nuclear respiratory factor 1; p = point mutation; PGC-1α = peroxisome proliferator-activated receptor gamma coactivator 1-α; PMID = PubMed Unique Identifier; SIRT = sirtuin; UTR = untranslated region.