TABLE 1.
Key findings on meningiomas in the last two decades.
| Year | Number of meningiomas sample |
Key findings | References | ||||
| Total | Grade I | Grade II | Grade III | Comment | |||
| 2004 | 72 | / | / | / | 58 benign, 10 atypical and 4 anaplastic meningiomas | The relationship between p53 gene mutation and p14 (ARF) gene methylation | (6) |
| 50 | 20 | 14 | 16 | / | The methylation of p16 (INK4a) | (7) | |
| 60 | 33 | 24 | 3 | / | The methylation of TP73 | (8) | |
| 2005 | 48 | / | / | / | 16 benign, 19 atypical, and 13 anaplastic meningiomas | The promoter hypermethylation is associated with atypical and anaplastic meningiomas; the methylation of MGMT | (9) |
| 44 | 15 | 11 | 8 | 10 meningiomas (grade I and grade II) | Hypermethylation of the NDRG2 promoter | (10) | |
| 2006 | 25 | / | / | / | Meningiomas without NF2 involvement | The methylation of NF2, p14 (ARF), CDH1, BRCA1, RB1 | (11) |
| 2007 | 40 | 22 | 11 | 7 | / | The methylation status of p73 or RASSF1A along with 1p LOH may result in the malignant transformation of a meningioma | (12) |
| 2009 | 26 | 10 | 7 | 9 | 209 tumors from 13 other tumor types; two human malignant meningioma cell lines: IOMM-Lee21 and KT21-MG1 | Aberrant methylation of the CpG island of WNK2 was associated with decreased expression in primary tumors | (13) |
| 2010 | 50 | 27 | 11 | 12 | / | The methylation of TIMP3 | (14) |
| 2011 | 65 | 26 | 27 | 12 | / | uPA Promoter Methylation | (15) |
| 2012 | 131 | 100 | 28 | 3 | / | The methylation of HOXA 7, 9, and 10 were associated with histopathology and clinical aggressiveness parameters | (16) |
| 36 | 16 | 17 | 3 | / | The methylation of MGMT, CDKN2A, GSTP1, and THBS1 | (17) | |
| 50 | 20 | 16 | 14 | / | Hypermethylation of the promoter of hMLH1 is associated with the tumor grade | (18) | |
| 2013 | 33 | 30 | 2 | 1 | Discovery set | The methylation of IGF2BP1 and PDCD1 | (19) |
| 12 | 6 | 5 | 1 | Verification set | |||
| 19 | 10 | 5 | 4 | / | Global DNA hypomethylation and the MAL2 gene | (20) | |
| 2015 | 44 | 33 | 2 | 9 | / | The methylation of CDKN2B, RASSF1A, RUNX3, AND GATA6 | (21) |
| 2016 | / | / | / | / | de novo tumors: 41 meningiomas and 33 hemangiopericytomas; recurrent tumors: 37 meningiomas and 5 hemangiopericytomas | The promoter methylation of hTERT was positively correlated with WHO grade and hTERT expression | (22) |
| 2017 | 497 | / | / | / | 309 samples of other extra-axial skull tumors | DNA Methylation-Based Classification | (23) |
| 89 | 54 | 34 | 1 | Test group | Robust DNA methylation signatures in meningioma were correlate with CNAs and could stratify patients by recurrence risk | (24) | |
| 51 | 36 | 9 | 6 | Validation group | |||
| 2019 | 282 | / | / | / | Training cohort: 228; the first validation cohort: 54 | Established a 5-year meningioma recurrence score | (4) |