Table 3.

Acquired T790M in different re-biopsy tissue specimens and the clinical factors.

	All patients	T790M(+)	T790M(–)	p
Total	407	215 (52.8%)	192 (47.2%)
Re-biopsy tissue specimens				0.286
Primary lung tumors	149	81 (54.4%)	68 (45.6%)
Pleural effusions/ascites	75	41 (54.7%)	34 (45.3%)
Cerebrospinal fluids	7	1 (14.3%)	6 (85.7%)
Plasma	68	38 (55.9%)	30 (44.1%)
Metastatic tumors	108	54 (50.0%)	54 (50.0%)	0.112#
Bone	65	33	32
Liver	13	10	3
Lymph node	20	7	13
Others	10	4	6
Re-biopsy tumor location*				0.101
Intra-thoracic	274	149 (54.4%)	125 (45.6%)
Extra-thoracic	65	28 (43.1%)	37 (56.9%)
Re-biopsy complication				0.259
Yes	24	10 (41.7%)	14 (58.3%)
No	383	205 (53.5%)	178 (46.5%)

^*Exclude plasma samples.

^#The comparison between the differnt metatsatic tumors. The italic value demonstrated the subgroups of different metastatic tumors.