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Proposed equilibrium of binding for albumin with FFA determined by lipid cells. Reversible albumin binding of both EGL proteins and FFA determines the concentrations non bound in plasma. If enough SARS-CoV-2 virions bind to albumin they will reduce the concentration of glycocalyx and thus deplete the endothelial glycocalyx layer. Similarly, excess FFA due to obesity causes reduction in the EDL or other ligands bound to albumin.
