Table 3.
Association of LEPR and ADIPOQ SNPs in the donors with delayed graft function one year after transplant and with the incidence of graft loss. B, regression coefficient; SE, standard error; df, degrees of freedom; OR, odds ratio; CI, 95% confidence interval. Results for delayed graft function were adjusted by age, BMI, diabetes, HCV infection, cause of donor death,acute rejection, use of basiliximab, HLA mismatch, cold ischemia time and revascularization time.,. For the graft loss model the covariates utilized were age, BMI, HLA mismatch, HCV infection, delayed graft function, diabetes, hypertension, history of CV events, hyperlipidemia, use of mycophenolate, use of basiliximab and acute rejection.
| B | SE | Wald | OR | CI | p | |
|---|---|---|---|---|---|---|
| Delayed graft function | ||||||
| LEPR rs1805094 | 0.706 | 0.356 | 3.930 | 2.03 | (0.99–4.07) | 0.051 |
| LEPR rs1137100 | −0.732 | 0.357 | 4.213 | 0.48 | (0.24–0.97) | 0.040 |
| LEPR rs1137101 | −0.756 | 0.359 | 4.430 | 0.47 | (0.23–0.95) | 0.035 |
| ADIPOQ rs1501299 | −0.481 | 0.349 | 1.901 | 0.62 | (0.31–1.23) | 0.168 |
| ADIPOQ rs2241766 | −0.354 | 0.378 | 0.877 | 0.70 | (0.33–1.47) | 0.349 |
| Graft loss | ||||||
| LEPR rs1805094 | 0.467 | 0.363 | 1.612 | 1.97 | (0.46–3.15) | 0.197 |
| LEPR rs1137100 | −0.310 | 0.380 | 0.656 | 0.65 | (0.32–1.49) | 0.430 |
| LEPR rs1137101 | −0.782 | 0.375 | 4.391 | 0.44 | (0.31–0.97) | 0.040 |
| ADIPOQ rs1501299 | 0.012 | 0.338 | 0.011 | 1.21 | (0.38–2.16) | 0.946 |
| ADIPOQ rs2241766 | −0.021 | 0.401 | 0.007 | 0.89 | (0.35–2.02) | 0.976 |