Table 2.
Patterns of failure and salvage treatments by treatment modality.
| Parameter | Total n = 201 (%) |
Surgery n = 172 (%) |
Radiotherapy n = 29 (%) |
|---|---|---|---|
| Follow-up (years) | |||
| Median | 3.2 | 3.1 | 4.0 |
| Range | (0.3–10.1) | (0.3–10.1) | (0.7–10.0) |
| Recurrences | 33 (16) | 30 (17) | 3 (10) |
| Local | 30 (15) | 28 (16) | 2 (7) |
| Regional | 8 (4) | 7 (4) | 1 (3) |
| Regional (w/o local) | 3 (1) | 2 (1) | 1 (3) |
| Distant | 4 (2) | 3 (2) | 1 (3) |
| 2 + recurrences | 10 (5) | 10 (6) | 0 |
| Time to 1st recurrence (months) | |||
| Median | – | 23.5 | 27.6 |
| Range | – | (1.4–88.4) | (5.6–60.9) |
| Treatment of 1st recurrence | |||
| RT alone | – | 4 | 0 |
| Cordectomy/Partial laryngectomy alone | – | 11 | 0 |
| CRT (definitive) | – | 1 | 0 |
| Total laryngectomy ± RT ± CT | – | 10 | 2 |
| Larynx-preserving surgery + RT ± CT | – | 3 | 0 |
| Palliative/None | – | 1 | 1 |
| Treatment of 2nd recurrence | |||
| RT alone | – | 0 | 0 |
| Cordectomy/Partial laryngectomy alone | – | 3 | 0 |
| CRT (definitive) | – | 0 | 0 |
| Total laryngectomy ± RT ± CT | – | 4 | 0 |
| Larynx-preserving surgery ± RT ± CT | – | 1 | 0 |
| Palliative/None | – | 2 | 0 |
| Total laryngectomy | 17 (8) | 15 (9) | 2 (7) |
| Deaths | 29 (14) | 24 (14) | 5 (17) |
| Cancer related | 7 (3) | 6 (3) | 1 (3) |
Abbreviation: RT = Radiotherapy; CT = Chemotherapy.