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. 2020 Jul 4;10(4):747–761. doi: 10.1016/j.jcmgh.2020.07.001

Figure 1.

Figure 1

Colonic weight-to-length ratios and histology of CD4-Cre+/TgMettl14FL/FL conditional knockout mice. (A) CD4+ and CD8+ T cells were isolated by FACS sorting and analyzed by Western blot for METTL14 and associated METTL3 expression. GAPDH is used as an internal control. (B) Hematoxylin and eosin stain of colon at 4 weeks of age. (C) Colonic weight-to-length ratio of mice at 6 and 24 weeks of age. Data are represented as mean ± SD. (D) Hematoxylin and eosin stain of colon at 24 weeks of age. (E) Anti-CD4 immunohistochemistry staining of colon cross-section at 24 weeks of age. n = 4–8 mice per group. Data representative of 2 independent experiments with similar results. WT indicates wild-type littermate control. KO indicates CD4-Cre+/TgMettl14FL/FL conditional knockout mouse.