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. 2020 Jul 4;10(4):747–761. doi: 10.1016/j.jcmgh.2020.07.001

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Cytokine expression profile of CD4-Cre^+/TgMettl14^FL/FL Conditional knockout mice. Relative expression of (A) Th1 cytokines IFNγ and TNFα; (B) Th17 cytokines IL-17a and IL-17c; (C) cytokines associated with inflammation including IL-1α, IL-1β, and IL-6; (D) Th2-potentiating cytokine IL-25 and Th2 cytokine IL-13; and (E) inhibitory cytokine IL-10. WT indicates wild-type littermate control. KO indicates CD4-Cre^+/TgMettl14^FL/FL conditional knockout. Log₂ scale was used on the y-axis for panels A–C; linear scale was used on the y-axis for panels D and E. Data are represented as mean ± SD. n = 4–8 mice per group. Data representative of 2 independent experiments with similar results.